Promising New Hope for Treatment-Resistant Depression: Stellate Ganglion Block


Major depressive disorder (MDD) is a global health concern, affecting millions of individuals worldwide. While various antidepressant treatments exist, a significant portion of patients suffering from MDD remain resistant to conventional therapies. This has spurred the search for innovative and effective treatments, leading researchers to explore the potential of Stellate Ganglion Block (SGB) as a promising solution.

What is Stellate Ganglion Block (SGB)?

SGB is a medical procedure primarily known for its use in pain management. It involves the injection of an anesthetic solution into the stellate ganglion, a cluster of nerves in the neck responsible for transmitting sympathetic signals to the brain. While initially employed for pain relief, recent studies have expanded the scope of SGB applications, particularly in the realm of psychiatric disorders.

The Local Injection For Treating Mood Disorders (LIFT-MOOD) Study:

Researchers recently conducted the LIFT-MOOD study to investigate the feasibility and potential of SGB as a treatment for individuals with treatment-resistant depression (TRD). This groundbreaking study utilized a randomized, placebo-controlled, pilot trial approach to assess various aspects, including recruitment rates, adherence, missing data, and adverse events.

Promising Feasibility Results:

The results of the LIFT-MOOD study are encouraging. The recruitment rate was reasonable and sufficient, indicating that individuals with TRD are willing to consider SGB as a potential treatment option. High retention and adherence rates and minimal missing data suggest that participants tolerated the procedure well. Importantly, adverse events were mild and temporary, further emphasizing the safety of SGB as a potential intervention.

Exploring Efficacy:

While the study primarily focused on feasibility, it also explored the efficacy of SGB in improving depressive symptoms. The active treatment group and the placebo group showed reductions in Montgomery-Åsberg Depression Rating Scale (MADRS) scores by the end of the study. However, it’s important to note that this pilot study had a small sample size, making it premature to conclude the effectiveness of SGB in treating TRD. Larger scale randomized controlled trials with more extended follow-up periods are needed to assess efficacy accurately.

The Promise of SGB for TRD:

The potential of SGB as a treatment for TRD is a ray of hope for individuals who have struggled to find relief through traditional antidepressants. SGB’s ability to modulate sympathetic input to the central nervous system opens new avenues for addressing depression, especially in cases where conventional treatments have fallen short.

Future Directions:

The success of the LIFT-MOOD study provides a strong foundation for future research. To further validate the efficacy of SGB in TRD, larger-scale studies are essential. Additionally, researchers should explore alternative sham procedures to ensure that observed improvements are attributable to SGB. Combining SGB with psychotherapy may also be a promising avenue for enhancing treatment outcomes.


The LIFT-MOOD study marks an exciting step forward in the quest to find effective treatments for treatment-resistant depression. While further research is needed to confirm SGB’s efficacy fully, the feasibility and safety demonstrated in this pilot study offer renewed hope to those suffering from this debilitating condition. As researchers continue to unlock the potential of SGB, we may be on the cusp of a groundbreaking breakthrough in the treatment of depression.

Local Injection for Treating Mood Disorders (LIFT-MOOD): A Pilot Feasibility RCT of Stellate Ganglion Block for Treatment-Resistant Depression

For additional information, please call or text:
Dariusz Nasiek, MD: tel. 201-894-1313, SMS: 973-773-7730
Allied Neurology & Interventional Pain Practice
Englewood Office: 185 Grand Ave. Englewood, NJ 07631
[email protected]


Victor M.
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Dr. Nasiek specializes in Interventional Pain, identifying the source of pain and providing solutions with expertise in anesthesiology and Interventional Pain Practice.